Collagen-induced arthritis in T cell receptor V beta congenic B10.Q mice.
Open Access
- 1 August 1994
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 180 (2), 517-524
- https://doi.org/10.1084/jem.180.2.517
Abstract
B10.Q (H-2q) mice congenic for the truncated T cell receptor (TCR) V beta a and V beta c haplotypes were derived to examine the influence of TCR V beta genomic deletions in murine collagen-induced arthritis (CIA). Previous studies using gene complementation and segregation analyses suggested that in SWR (H-2q) mice, possession of the V beta a gene deletion results in CIA resistance. However, other studies have suggested alternative hypotheses. Thus, analysis of TCR V beta congenic mice allows for direct examination of V beta genotypes in CIA control. After immunization with bovine type II collagen, B10.Q-V beta a mice showed no difference in arthritis susceptibility, onset, or severity when compared with prototype B10.Q mice. In contrast, B10.Q-V beta c mice, which lack the V beta 6, 15, 17, and 19 families in addition to the V beta a deletion, were highly resistant to CIA. In vivo depletion of V beta 6+ T cells in B10.Q-V beta a mice significantly delayed arthritis onset suggesting that, among those V beta genes present in V beta a but absent in V beta c, V beta 6+ T cells contribute to arthritogenesis. Our findings show that, in B10.Q-V beta congenic mice, while the V beta a genotype does not prevent CIA, the highly truncated V beta c genotype renders B10.Q mice resistant to CIA. Thus, deletions within the V beta TCR genome can indeed influence CIA and suggests that the TCR repertoire displays only marginal flexibility in response to arthritogenic stimuli.Keywords
This publication has 45 references indexed in Scilit:
- Characterization of a rat monoclonal antibody specific for a determinant encoded by the V beta 7 gene segment. Depletion of V beta 7+ T cells in mice with Mls-1a haplotype.The Journal of Immunology, 1990
- Coding sequence polymorphisms among V beta T cell receptor genes.The Journal of Immunology, 1990
- INVIVO ELIMINATION OF T-CELLS EXPRESSING SPECIFIC T-CELL RECEPTOR-V-BETA CHAINS IN MICE SUSCEPTIBLE TO COLLAGEN-INDUCED ARTHRITIS1990
- Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells.The Journal of Experimental Medicine, 1989
- RIII S/J (H-2r). An inbred mouse strain with a massive deletion of T cell receptor V beta genes.The Journal of Experimental Medicine, 1989
- Influence of complement C5 and V beta T cell receptor mutations on susceptibility to collagen-induced arthritis in mice.The Journal of Immunology, 1989
- The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.The Journal of Experimental Medicine, 1989
- Identification of T-cell receptor V ? deletion mutant mouse strain AU/ssJ (H-2 q ) which is resistant to collagen-induced arthritisImmunogenetics, 1989
- In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice.The Journal of Immunology, 1988
- The progression of the inflammation in established collagen‐induced arthritis can be altered by treatments with immunological or pharmacological agents which inhibit T cell activitiesEuropean Journal of Immunology, 1988