The Absorption Characteristics of Paracetamol Tablets in Man

Abstract

Paracetamol tablets from different sources showed widely differing absorption patterns in man. As judged by a blood concentration at 45 min. of less than 10 μg./ml. whole blood, low absorption was usually found in 25 per cent of subjects. This may be reduced to less than 10 per cent by a new paracetamol/sorbitol tablet. This combination produced higher average blood levels at 45 min. than crushed tablets of paracetamol. There appears to be a relation between the absorption of the drug and both age and weight; this variation can be reduced by paracetamol/sorbitol.