F-Cell Production in Sickle Cell Anemia: Regulation by Genes Linked to β-Hemoglobin Locus
- 27 March 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 211 (4489), 1441-1444
- https://doi.org/10.1126/science.6162200
Abstract
Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the beta S-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.This publication has 19 references indexed in Scilit:
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