Regulatory interrelations between GABA and polyamines. I. Brain GABA levels and polyamine metabolism
- 1 August 1979
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 4 (4), 425-435
- https://doi.org/10.1007/bf00964637
Abstract
Elevation of brain GABA levels by GABA-T inhibition is accompanied by a decrease ofS-adenosylmethionine decarboxylase activity. This is followed by an increase of ornithine decarboxylase activity and a severalfold increase of brain putrescine levels. Spermidine and spermine levels are not significantly affected under these conditions. These unexpected findings support a regulatory interaction between GABA and polyamine metabolism.Keywords
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