THE EFFECT OF HEMORRHAGE ON NORMAL AND HYPOCOAGULABLE BLOOD AND LYMPH

Abstract

As a result of rapid progressive hemorrhage in normal dogs, the coagulability of the blood, the plasma, and the lymph was increased. In dogs whose blood was rendered hypocoagulable by the inj. of protamine, peptone, or heparin, there was also an acceleration of the clotting time of the blood and blood plasma. However the lymph in the protamine and peptone injected animals remained hypocoagulable. The cause for the increased coagulability was sought for by quantitative detns. of prothrombin, antithrombin, and fibrinogen in the blood and lymph. The latter coagulation factors did not account for the alterations in the coagulation time of the blood which appeared to be due to increased mobilization of thromboplastin.