Gonadotrophic Hormone Excretion of the Pregnant Monkey (Macaca mulatto).

Abstract

Urinary excretion of gonadotropin by pregnant Macaca mulatta was assayed at intervals from the 22nd to 179th day of gestation. Hypophysectomized immature female rats were injected with concentrates equivalent to 1/4 day''s output of urine. Only urine excreted between the 22nd and 34th day of pregnancy had a gonadotropic action, and the action was restricted to repair of interstitial tissue. Gonadotropic stimulus seen in normal immature rats was comparable to that from low doses of human chorionic gonadotropin during this extremely limited pregnancy period.