RELATIVE POTENCY OF ORG NC 45, PANCURONIUM, ALCURONIUM AND TUBOCURARINE IN ANAESTHETIZED MAN
Open Access
- 1 August 1980
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 52 (8), 783-788
- https://doi.org/10.1093/bja/52.8.783
Abstract
The relative potency, time-course of action and cardiovascular effects of Org NC 45, a new non-depolarizing neuromuscular blocking agent, have been compared with those of pancuronium, alcuronium and tubocurarine in 64 anaesthetized patients. The relative potency (ED50) to Org NC45 was 1.74, 3.69 and 8.57 respectively. In doses which caused useful surgical relaxation, duration of action of Org NC 45 was 34%, 39% and 26% that of pancuronium, alcuronium and tubocurarine. After administration of repeated doses no cumulation was seen for Org NC 45. The new drug was free from any effect on arterial pressure and heart rate.This publication has 4 references indexed in Scilit:
- The Emergence of ORG NC 45, 1- [(2β,3α, 5α,16β, 17β)-3, 17-BIS(Acetyloxy)-2-(1-Piperidinyl)-Androstan-16-YL]-1-Methylpiperidinium Bromide, from the Pancuronium SeriesBritish Journal of Anaesthesia, 1980
- The Neuromuscular Blocking Action of ORG NC 45, A New Pancuronium Derivative, in Anaesthetized PatientsBritish Journal of Anaesthesia, 1980
- First Clinical Experiences with ORG NC 45British Journal of Anaesthesia, 1980
- COMBINED I.V. BOLUS AND INFUSION OF PANCURONIUM BROMIDEBritish Journal of Anaesthesia, 1978