S-100 PROTEIN IN LANGERHANS CELLS, INTERDIGITATING RETICULUM CELLS AND HISTIOCYTOSIS X-CELLS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 73 (3), 429-432
Abstract
S-100 protein was immunohistochemically demonstrated in the cells of [human] cases of histiocytosis X such as eosinophilic granuloma, Hand-Schueller-Christian disease and Letterer-Siwe disease. Its presence was also shown in Langerhans cells of the epidermis and interdigitating reticulum cells in the lymph node, spleen and thymus. S-100 protein was not found in epithelioid cells in sarcoidosis, phagocytic macrophages or dendritic reticulum cells in germinal centers. S-100 protein might be a new immunohistochemical marker for the Langerhans cells, interdigitating reticulum cells and histiocytosis X cells.