Effect of Salicylic Acid on Adrenal-Pituitary System. III. Studies on Mechanism of This Effect
- 1 July 1954
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 86 (3), 409-413
- https://doi.org/10.3181/00379727-86-21116
Abstract
The effect of a single injection of salicylic acid (300 mg/kg) lasted more than 16 hours, at which time still appreciable blood-levels of salicylic acid were present. Repeated injections of salicylic acid did not impair the responsiveness of the adrenals. Pretreatment with cortisone reduced, but did not abolish the effect of salicylic acid. Complete anesthesia with pentobarbital blocked the effect of salicylic acid. Results are interpreted as an effect of salicylic acid on the hypothalamus with subsequent stimulation of the pituitary.Keywords
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