Posttreatment with Amino Compounds Effective in Prevention of Calcification of Glutaraldehyde Treated Pericardium
- 1 May 1994
- journal article
- Published by Wiley in Artificial Organs
- Vol. 18 (5), 408-410
- https://doi.org/10.1111/j.1525-1594.1994.tb02223.x
Abstract
An attempt has been made to compare the role of different amino compounds in prevention of calcification of glutaraldehyde (GA)-treated pericardium implanted subcutaneously in the rat for 12 weeks. GA pretreated pericardial samples were postfixed separately with glycine, albumin, gentamicin, glycine + gentamicin, and albumin + gentamicin. Severe calcification was noticed in animals undergoing albumin or gentamicin postfixation. Mild calcification was observed in glycine and albumin + gentamicin postfixed materials whereas calcium was undetectable either chemically or morphologically in GA-pretreated pericardium postfixed with glycine + gentamicin (0.32 +/- 0.13.mg/g calcium, dry wt; von Kossa 0) at the 12th week of implantation in the rat.Keywords
This publication has 3 references indexed in Scilit:
- Decreased tissue reaction to bioprosthetic heart valve material afterL-glutamic acid treatment. A morphological studyJournal of Biomedical Materials Research, 1992
- Prevention of bioprosthetic heart valve tissue calcification by charge modification: Effects of protamine binding by formaldehyde3Journal of Biomedical Materials Research, 1991
- Possible causes for the calcification of glutaraldehyde-treated tissue heart valves and blood contacting elastomers during prolonged use in medical devices: a physico-chemical viewBiomaterials, 1981