Structural and compositional changes associated with chlorine inactivation of polioviruses
- 1 December 1979
- journal article
- research article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 38 (6), 1034-1039
- https://doi.org/10.1128/aem.38.6.1034-1039.1979
Abstract
Chlorine inactivation of polioviruses resulted in the loss of viral ribonucleic acid, converting the viruses from 156S particles to 80S particles. However, it was found that virus inactivation occurred before the ribonucleic acid was released from the virions. Extraction of ribonucleic acid from partially inactivated virus suspensions indicated that chlorine inactivation was due to degradation of the ribonucleic acid before release and that ribonucleic acid loss was a secondary event. The empty 80S capsids had the same isoelectric point and ability to attach to host cells as infective virions. Thus, no major capsid conformational changes occurred during chlorine inactivation.This publication has 9 references indexed in Scilit:
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