INFLUENCE OF INGESTED FOODS ON THE ORAL TOXICITY IN MICE OF CRYSTALLINE BOTULINAL TYPE A TOXIN

Abstract

The potency of orally administered crystalline type A botulinal toxin is influenced by ingested foods. The tendency is for commercial mouse pellet feed, egg albumin and olive oil to increase toxic potency, and skim milk powder to decrease potency. During a meal, brandy would have to be consumed in copious quantity to effect significant decreases in oral toxicity. Quantitative statements of oral toxicity, to be most meaningful, should include information on the state of food consumption by test animals.