CHANGE IN AFFINITY OF INSULIN RECEPTORS FOLLOWING ORAL GLUCOSE IN NORMAL ADULTS
- 1 June 1977
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 44 (6), 1206-1209
- https://doi.org/10.1210/jcem-44-6-1206
Abstract
125I-insulin binding to circulating monocytes was studied in 4 normal volunteers in the basal state and at 2 and 5 h after ingestion of 100 g of glucose. In each study 5 h after glucose ingestion, the competition-inhibition curve was shifted to the left and was steeper than that in the basal study; the amount of insulin that caused a 50% decrease in specific binding of 125I-insulin in the basal study was 3-11 fold higher than at 5 h after glucose. These changes in binding after glucose ingestion were largely due to major alterations of receptor affinity. Acute changes in receptor affinity occur normally as part of the physiologic regulation of target cell sensitivity to hormonal stimulation.This publication has 7 references indexed in Scilit:
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