UREMIA AND DISSEMINATED PLATELET-CELL (THROMBOCYTE) THROMBOSIS

Abstract

THE CASE described in this study presents several unusual features: 1. No other case of clinical uremia due to malignant nephrosclerosis, acute pancreatitis, and proved platelet-cell thrombosis appears in the literature. There has been one somewhat similar case without platelet-cell thrombosis reported by Gambill.¹ 2. The entity, platelet-cell thrombosis, verified at necropsy, has been reported in only about 25 cases, and in only 2 cases was the diagnosis made or suspected ante mortem.² In the case to be presented, the diagnosis of platelet-cell thrombosis was made post mortem. Historically, the subject of pancreatic function and pancreatitis has been aptly recorded by many authors and requires little discussion here.³ In brief, acute pancreatitis was first described as a clinical entity by Fitz in 1889. Claude Bernard suggested that the cause was autodigestion due to the activation of the pancreatic enzymatic secretions. This is reflected in our present use