Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat.
- 1 May 1994
- journal article
- abstracts
- Published by Wolters Kluwer Health in Circulation
- Vol. 89 (5), 2273-2282
- https://doi.org/10.1161/01.cir.89.5.2273
Abstract
BACKGROUNDAfter myocardial infarction, the noninfarcted left ventricle develops reactive hypertrophy associated with a depressed coronary flow reserve, myocardial interstitial fibrosis, and reduced capillary density. The present study investigated the comparative cardiac effects of chronic angiotensin-converting enzyme (ACE) inhibition and selective angiotensin II type 1 receptor (AT1) blockade in the rat model of myocardial infarction and failure.METHODS AND RESULTSSeven days after coronary ligation (MI), rats were randomized to enalapril (n = 8; 500 micrograms.kg-1.d-1), losartan (n = 9; 3 mg.kg-1.d-1), or placebo (n = 8) and treated for 6 weeks. Sham-operated rats (n = 10) served as controls. Coronary blood flow was measured with radiolabeled microspheres during baseline and maximal coronary dilation induced by dipyridamole (2 mg.kg-1.min-1 over 10 minutes). Right and left ventricular (LV) weight was increased in infarcted rats compared with sham-operated animals and enalapril- and losartan-treated MI ...Keywords
This publication has 29 references indexed in Scilit:
- Effects of losartan on blood pressure, plasma renin activity, and angiotensin II in volunteers.Hypertension, 1993
- Selective Activation of Cardiac Angiotensinogen Gene Expression in Post-infarction Ventricular Remodeling in the RatJournal of Molecular and Cellular Cardiology, 1993
- Collagen deposition and the reversal of coronary reserve in cardiac hypertrophy.Hypertension, 1992
- Ramiprilat enhances endothelial autacoid formation by inhibiting breakdown of endothelium-derived bradykinin.Hypertension, 1991
- Capillary neoformation in the rat heart-stereological studies on papillary muscles in hypertrophy and physiologic growthBasic Research in Cardiology, 1990
- Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.Journal of Clinical Investigation, 1989
- Effect of Captopril on Progressive Ventricular Dilatation after Anterior Myocardial InfarctionNew England Journal of Medicine, 1988
- Effects of arterial vasodilators on cardiac hypertrophy and sympathetic activity in rats.Hypertension, 1988
- Multiple simultaneous determinations of hemodynamics and flow distribution in conscious ratJournal of Pharmacological Methods, 1984
- Long-Term Preservation of Ischemic Myocardium after Experimental Coronary Artery OcclusionJournal of Clinical Investigation, 1978