A Lipid Anticoagulant from Brain Tissue. Physiochemical Characteristics and Action in vitro and in vivo

Abstract

A heat-labile lipid inhibitor of blood coagulation was extracted from brain tissue, differing in potency, solubility, chemical nature and physiologic action from other known anticoagulants. It has a pronounced antithromboplastic activity especially against homologous brain extracts in homologous plasma. Though the anticoagulant power of this lipid antithromboplas- tin "in vitro" is still less than that of heparin, it has "in vivo" a more lasting effect when injected intraven. than a soln. of heparin of equivalent anticoagulant potency.