THE SYNTHESIS AND OPIATE ACTIVITY OF HUMAN β-ENDORPHIN ANALOGS
- 12 January 2009
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 11 (5), 323-328
- https://doi.org/10.1111/j.1399-3011.1978.tb02856.x
Abstract
Four analogs of human .beta.-endorphin were synthesized and their opiate activities were determined in guinea pig. One of the analogs, [27-phenylalanine, 32-glycine]-.beta.h-endorphin, was shown to possess an analgesic potency greater than that of the natural peptide in mice.Keywords
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