ARF family G proteins and their regulators: roles in membrane transport, development and disease
Top Cited Papers
- 18 May 2011
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 12 (6), 362-375
- https://doi.org/10.1038/nrm3117
Abstract
The ADP-ribosylation factor (ARF) family of guanine-nucleotide-binding (G) proteins, including the ARF proteins, ARF-like (ARL) proteins and SAR1, regulates membrane traffic and organelle structure, and each family member is regulated through a cycle of GTP binding and GTP hydrolysis, which activate and inactivate, respectively, the G protein. Traditionally, ARFs have been characterized for their immediate effects in the recruitment of coat proteins to drive cargo sorting, the recruitment of enzymes that can alter membrane lipid composition and the regulation of cytoskeletal factors. Now, new roles for ARFs have been discovered at the Golgi complex, for example in driving lipid transport. ARL proteins are also being increasingly linked to coordination of trafficking with cytoskeletal processes, for example during ciliogenesis. There is particular interest in the mechanisms that control recruitment of the ARF guanine nucleotide exchange factors (GEFs) that mediate GTP binding to ARFs and, in the case of the cytohesin (also known as ARNO) GEF, membrane recruitment is coupled to relief of autoinhibition. GEFs such as cytohesin may also participate in a cascade of activation between particular pairs of ARFs. Traditionally, G protein signalling has been viewed as a linear pathway, with the GDP-bound form of an ARF protein being inactive; however, more recent studies have highlighted novel roles for these GDP-bound forms and have also shown that GEFs and GTPase-activating proteins (GAPs) themselves can engage in distinct signalling responses through scaffolding functions.Keywords
This publication has 140 references indexed in Scilit:
- Decoupling of Activation and Effector Binding Underlies ARF6 Priming of Fast Endocytic RecyclingCurrent Biology, 2011
- TBC1D24, an ARF6-Interacting Protein, Is Mutated in Familial Infantile Myoclonic EpilepsyAmerican Journal of Human Genetics, 2010
- An Arf-like Small G Protein, ARL-8, Promotes the Axonal Transport of Presynaptic Cargoes by Suppressing Vesicle AggregationNeuron, 2010
- The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to CiliaCell, 2010
- Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA ReplicationCell, 2010
- Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout miceBrain Research, 2010
- Impaired fear response in mice lacking GIT1Neuroscience Letters, 2009
- ARF6 Interacts with JIP4 to Control a Motor Switch Mechanism Regulating Endosome Traffic in CytokinesisCurrent Biology, 2009
- Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange FactorsMolecular Cell, 2007
- Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII VesicleCell, 2005