TRIMETHOPRIM-RESISTANT BACTERIA - CROSS-RESISTANCE PATTERNS
- 1 January 1977
- journal article
- research article
- Vol. 19 (75), 45-53
Abstract
Clinically isolated trimethoprim-resistant bacteria (181 strains) were tested for sensitivity to proguanil, pyrimethamine, methotrexate and methasquin. All these agents had less intrinsic bacterial activity than trimethoprim, and there was marked cross-resistance between trimethoprim on the 1 hand and pyrimethamine and methasquin on the other. Methotrexate was of very low activity against gram-negative bacilli, but was highly inhibitory for streptococci. Proguanil had approximately the same activity for all the organisms tested, and appears not to act as an anti-folate agent.This publication has 5 references indexed in Scilit:
- Differentiating Properties of the Dihydrofolate Reductases of Amethopterin-resistant Streptococcus faecalis/Ak and the Sensitive Parent StrainJournal of Biological Chemistry, 1966
- INHIBITOR BINDING ANALYSIS OF DIHYDROFOLATE REDUCTASES FROM VARIOUS SPECIES1965
- The relationship of cellular permeability to the degree of inhibition by amethopterin and pyrimethamine in several species of bacteriaBiochemical Pharmacology, 1961
- The Pharmacological Basis for the Prolonged Antimalarial Activity of PyrimethamineThe American Journal of Tropical Medicine and Hygiene, 1957
- The Absorption and Excretion of Paludrine in the Human SubjectPathogens and Global Health, 1946