Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1
- 13 June 1997
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 276 (5319), 1699-1702
- https://doi.org/10.1126/science.276.5319.1699
Abstract
Extracellular levels of the excitatory neurotransmitter glutamate in the nervous system are maintained by transporters that actively remove glutamate from the extracellular space. Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury. These effects can be attributed to elevated levels of residual glutamate in the brains of these mice.Keywords
This publication has 26 references indexed in Scilit:
- EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapsesNeuroReport, 1996
- Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosisAnnals of Neurology, 1995
- Kinetics of a human glutamate transporterNeuron, 1995
- Molecular cloning of two glutamate transporter subtypes from mouse brainBiochimica et Biophysica Acta (BBA) - General Subjects, 1995
- Mouse Excitatory Amino Acid Transporter EAAT2: Isolation, Characterization, and Proximity to Neuroexcitability Loci on Mouse Chromosome 2Genomics, 1994
- Localization of neuronal and glial glutamate transportersNeuron, 1994
- The elusive transporters with a high affinity for glutamateTrends in Neurosciences, 1993
- Effect of Noncompetitive Blockade of N‐Methyl‐d‐Aspartate Receptors on the Neurochemical Sequelae of Experimental Brain InjuryJournal of Neurochemistry, 1990
- The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brainCell, 1990
- Glutamate neurotoxicity and diseases of the nervous systemNeuron, 1988