REDUCTION IN BRAIN SEROTONIN SYNTHESIS RATE IN STREPTOZOTOCIN-DIABETIC RATS1
- 1 July 1981
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 109 (1), 310-312
- https://doi.org/10.1210/endo-109-1-310
Abstract
The rate of serotonin synthesis in brain was determined in streptozotocin-diabetic and normal rats using two methods. Both the rate of 5-hydroxytryptophan accumulation after aromatic amino acid decarboxylase inhibition, and the decline rate of 5-hydroxyindole acetic acid after pargyline treatment were significantly reduced in diabetic rats. The reduced rate of synthesis may be a direct result of significantly lowered brain tryptophan levels in diabetic rats.Keywords
This publication has 7 references indexed in Scilit:
- INCREASED TRYPTOPHAN-HYDROXYLASE ACTIVITY MAY COMPENSATE FOR DECREASED BRAIN TRYPTOPHAN LEVELS IN STREPTOZOTOCIN-DIABETIC RATS1980
- REGIONAL ACCUMULATION OF TRYPTOPHAN AND SEROTONIN METABOLISM FOLLOWING TRYPTOPHAN LOADING IN DIABETIC RATSJournal of Neurochemistry, 1978
- EFFECTS OF INSULIN AND STREPTOZOTOCIN–NDUCED DIABETES ON BRAIN TRYPTOPHAN AND SEROTONIN METABOLISM IN RATSJournal of Neurochemistry, 1978
- Brain serotonin synthesis: reduction in corn‐malnourished rats1Journal of Neurochemistry, 1977
- TRANSPORT OF METABOLIC SUBSTRATES THROUGH THE BLOOD‐BRAIN BARRIER1Journal of Neurochemistry, 1977
- The Determination of Glucose by the Ortho-Toluidine Method (Filtrate and Direct Procedure)Published by Elsevier ,1970
- DETERMINATION OF TRYPTOPHAN IN PLASMA LIVER AND URINE1967