Localization of Antigenic Determinants in the Polypeptide Chains of Collagen
- 19 December 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 166 (3912), 1522-1524
- https://doi.org/10.1126/science.166.3912.1522
Abstract
After being injected with collagen from rat or guinea pig skin, rabbits form high titer, species-specific antibodies to collagen. Antibody is directed primarily against the α2 chain of collagen with little reaction With the αl chain. The amino terminal peptide of cyanogen bromide cleavage of the α2 chain of guinea pig skin collagen, α2-CBl, effectively inhibited the antigen-antibody reaction, an indication that a major antigenic determinant of collagen is located at the amino terminal of the α2 chain.Keywords
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