Hereditary multiple exostosis
- 1 May 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Heredity
- Vol. 78 (3), 171-177
- https://doi.org/10.1093/oxfordjournals.jhered.a110351
Abstract
Hereditary multiple exostosis (HME), a bone tumor first described by Virchow, has been studied over a period of 15 years on a comparative basis. The horse, an excellent biomedical model for this physically deforming multiple bone tumor in man, has been utilized in this study. The etiology, hereditary pattern, potential for malignancy and other aspects of this strange affliction need additional clarification. This in–depth study of 261 individuals from 144 families was compared with that of 55 horses bearing the HME trait, selectively bred and studied over the same period. Important information has been collected and evaluated about this condition that is suspect of being frequently missed diagnostically, with a higher incidence in humans than recognized. Continuing development studies of offspring of the original study participants; sarcomatous transformation monitoring; and recently developed genetic techniques should add to our understanding of this puzzling hereditary condition.This publication has 3 references indexed in Scilit:
- Detailed description and nomenclature of high resolution G-banded horse chromosomesJournal of Heredity, 1984
- HEREDITARY MULTIPLE EXOSTOSES - CLINICOPATHOLOGIC FEATURES OF A COMPARATIVE-STUDY IN HORSES AND MAN1979
- Myositis ossificans progressivaAmerican Journal Of Medicine, 1964