Effects of Reducing Dietary Saturated Fatty Acids on Plasma Lipids and Lipoproteins in Healthy Subjects
- 1 March 1998
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 18 (3), 441-449
- https://doi.org/10.1161/01.atv.18.3.441
Abstract
—Few well-controlled diet studies have investigated the effects of reducing dietary saturated fatty acid (SFA) intake in premenopausal and postmenopausal women or in blacks. We conducted a multicenter, randomized, crossover-design trial of the effects of reducing dietary SFA on plasma lipids and lipoproteins in 103 healthy adults 22 to 67 years old. There were 46 men and 57 women, of whom 26 were black, 18 were postmenopausal women, and 16 were men ≥40 years old. All meals and snacks, except Saturday dinner, were prepared and served by the research centers. The study was designed to compare three diets: an average American diet (AAD), a Step 1 diet, and a low-SFA (Low-Sat) diet. Dietary cholesterol was constant. Diet composition was validated and monitored by a central laboratory. Each diet was consumed for 8 weeks, and blood samples were obtained during weeks 5 through 8. The compositions of the three diets were as follows: AAD, 34.3% kcal fat and 15.0% kcal SFA; Step 1, 28.6% kcal fat and 9.0% k...Keywords
This publication has 53 references indexed in Scilit:
- Diet and drug therapy for lipoprotein (a)Current Opinion in Lipidology, 1995
- Can lifestyle changes reverse coronary heart disease?The Lancet, 1990
- Reduction of Plasma Cholesterol Levels in Normal Men on an American Heart Association Step 1 Diet or a Step 1 Diet with Added Monounsaturated FatNew England Journal of Medicine, 1990
- Effect of a Diet Enriched with Monounsaturated or Polyunsaturated Fatty Acids on Levels of Low-Density and High-Density Lipoprotein Cholesterol in Healthy Women and MenNew England Journal of Medicine, 1989
- Diet and 20-Year Mortality from Coronary Heart DiseaseNew England Journal of Medicine, 1985
- EFFECT OF DIET AND SMOKING INTERVENTION ON THE INCIDENCE OF CORONARY HEART DISEASEThe Lancet, 1981
- High Density Lipoprotein Metabolism in ManJCI Insight, 1977
- Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: Demographic, physical, dietary and biochemical characteristicsJournal of Chronic Diseases, 1974
- CONTROLLED TRIAL OF A DIET HIGH IN UNSATURATED FAT FOR PREVENTION OF ATHEROSCLEROTIC COMPLICATIONSThe Lancet, 1968
- Chapter XVII: Faribault Second StudyCirculation, 1968