Myeloid differentiation (MyD) primary response genes in hematopoiesis
Open Access
- 13 May 2002
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 21 (21), 3391-3402
- https://doi.org/10.1038/sj.onc.1205312
Abstract
Myeloid Differentiation (MyD) primary response and Growth Arrest DNA-Damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45α MyD118/Gadd45β, GADD45γ, MyD116/Gadd34) genes, that have been cloned by virtue of there being co-ordinately induced upon the onset of terminal myeloid differentiation. This review delineates the role MyD genes play in blood cell development, where they function as positive regulators of terminal differentiation, lineage specific blood cell development and control of blood cell homeostasis, including growth inhibition and apoptosis.Keywords
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