Systemic Adenosine Infusion Alleviates Spontaneous and Stimulus Evoked Pain in Patients with Peripheral Neuropathic Pain
- 1 October 1995
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 81 (4), 713-717
- https://doi.org/10.1097/00000539-199510000-00010
Abstract
In seven patients with peripheral neuropathic pain, the effect of systemic adenosine infusion on pain symp- toms was evaluated in a double-blind, placebo con- trolled, cross-over study. The study infusions, adeno- sine (50 pgkg-'*min-') or placebo, were given intravenously (IV) during 45-60 min at two separate occasions. Before and during infusions, bedside exami- nation of sensibility and quantitative sensory testing (QST), i.e., assessments of perception thresholds for touch, touch-evoked pain, cold, warmth, painful heat, and cold, were performed. In the neuropathic area, sen- sation magnitude was rated by a visual analog scale (100 mm VAS) using a pin and at perception threshold for touch-evoked pain using von Frey filaments. Aden- osine infusion reduced spontaneous pain (P < 0.05), and caused an increase of the touch-evoked pain threshold from 10.8 + 5.3 to 22.2 + 6.9 g (P < 0.05), whereas placebo had no effect. Pain intensity at percep- tion threshold for touch-evoked pain was, however, un- altered. Pinprick-evoked pain in the neuropathic areas was reduced from 53 ? 11 to 29 ? 10 mm (P < 0.05). No other sensory modality was consistently changed dur- ing adenosine infusion. In conclusion, the present study demonstrates that adenosine infusion alleviates spon- taneous neuropathic pain, tactile allodynia, and pin- prick hyperalgesia in patients with peripheral neuro- pathic disorders, probably by a central mechanism of action.Keywords
This publication has 15 references indexed in Scilit:
- Systemic adenosine infusion: a new treatment modality to alleviate neuropathic painPain, 1995
- Systemic adenosine attenuates touch evoked allodynia induced by mustard oil in humansNeuroReport, 1995
- The Influence of Adenosine, Ketamine, and Morphine on Experimentally Induced Ischemic Pain in Healthy VolunteersAnesthesia & Analgesia, 1994
- Adenosine infusion during isoflurane-nitrous oxide anaesthesia: indications of perioperative analgesic effectActa Anaesthesiologica Scandinavica, 1992
- Studies of heat pain sensation in man: perception thresholds, rate of stimulus rise and reaction timePain, 1990
- The role of purines in nociceptionNeuroscience, 1989
- Adenosine injection into the brachial artery produces ischaemia like pain or discomfort in the forearmCardiovascular Research, 1988
- Does acute intraoral pain alter cutaneous sensibility?Journal of Neurology, Neurosurgery & Psychiatry, 1988
- Cardiovascular and respiratory effects of adenosine in conscious man. Evidence for chemoreceptor activation.Circulation Research, 1987
- Angina pectoris-like pain provoked by intravenous adenosine in healthy volunteers.BMJ, 1986