Absence of Late-Replicating X-Chromosome in a Female Patient With Acute Myeloid Leukemia and the 8;21 Translocation2
- 1 February 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 62 (2), 273-275
- https://doi.org/10.1093/jnci/62.2.273
Abstract
Autoradiography was used to demonstrate that the X-chromosome of the 45,X, - X,t(8;21) stemline of a female patient with acute myeloid leukemia (AML) was the active X-chromosome. This suggested that in patients housing AML with the 8;21 translocation, the loss of the inactive X-chromosome in females and of the Y in males (which is known to occur in nearly half of the patients) entails selective advantage to the stemline.Keywords
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