Long-Term Amphetamine Treatment Decreases Brain Serotonin Metabolism: Implications for Theories of Schizophrenia
- 21 September 1979
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 205 (4412), 1295-1297
- https://doi.org/10.1126/science.572992
Abstract
Long-term amphetamine administration to cats (a mean of 8.75 milligrams per kilogram twice daily for 10 days) produced large decreases (40 to 67 percent in serotonin and its major metabolite, 5-hydroxyindoleacetic acid, in all brain regions examined. This treatment also produced several behaviors that are dependent on depressed central serotonergic neurotransmission, and which normally are elicited exclusively by hallucinogenic drugs. Short-term amphetamine administration (15 mg/kg) did not produce these behaviors and resulted in small decreases in brain serotonin and no change in 5-hydroxyindoleacetic acid. These data are discussed in the context of monoamine theories of schizophrenia.Keywords
This publication has 26 references indexed in Scilit:
- Long-Term Changes in Dopaminergic Innervation of Caudate Nucleus After Continuous Amphetamine AdministrationScience, 1978
- Behavioral effects of LSD in the cat: Proposal of an animal behavior model for studying the actions of hallucinogenic drugsBrain Research, 1977
- An Animal Behavior Model for Studying the Actions of LSD and Related HallucinogensScience, 1976
- LSD acts synergistically with serotonin depletion: Evidence from behavioral studies in catsPharmacology Biochemistry and Behavior, 1976
- The dopamine receptor: Differential binding of d-LSD and related agents to agonist and antagonist statesLife Sciences, 1975
- LSD as an agonist and antagonist at central dopamine receptorsNature, 1974
- LSD as an agonist of dopamine receptors in the striatumNature, 1974
- Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypyPharmacology Biochemistry and Behavior, 1974
- Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain RapheScience, 1968
- Comparison of Amphetamine Psychosis and SchizophreniaThe British Journal of Psychiatry, 1965