Age-Related Changes in Enzymes of Rat Brain
- 1 July 1981
- journal article
- research article
- Published by S. Karger AG in Enzyme
- Vol. 26 (5), 271-276
- https://doi.org/10.1159/000459190
Abstract
Measurements have been made of the enzymes of glutathione metabolism and of NADPH generation in the brains of rats aged between 1 day and 24 months. The activity of glutathione peroxidase fell while that of glutathione reductase rose during the aging process. The four NADPH-generating systems each showed a different profile with respect to aging, the most marked changes occurring between 1 day and 20 days. Subsequently, the systems remained close to, or above, the young adult value. The role of the glutathione-metabolising enzymes in controlling the H(2)0(2) metabolism and suppressing peroxidative damage to the brain is discussed.Keywords
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