Immunodepression inBabesia microtiinfections
- 1 October 1977
- journal article
- research article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 75 (2), 197-205
- https://doi.org/10.1017/s003118200006234x
Abstract
Infection with the avirulent piroplasm Babesia microti in mice is accompanied by a marked depression in the ability of the mice to mount an immune response to sheep red blood cells. The period of immunodepression begins 3 days after peak parasitaemia and is maximal 4 days later. There-after, there is a slow return to normal immune responsiveness, correlated with the gradual disappearance of the parasites from the blood. Both IgM and IgG responses are depressed. Cell-mediated responses as determined by contact sensitivity to oxazolone and allograft survival are apparently unaffected. Phagocytic activity as measured by carbon clearance tests is increased, and is correlated with the parasitaemia.This publication has 14 references indexed in Scilit:
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