Mouse Chromosome Translocations: Visualization and Analysis by Electron Microscopy of the Synaptonemal Complex
- 20 May 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 196 (4292), 892-894
- https://doi.org/10.1126/science.870966
Abstract
Pachytene chromosomes of mice heterozygous for known translocations are clearly depicted by configurations of the synaptonemal complexes in spread (whole mount) preparations. In one autosomal and two X-autosome translocations analyzed, breakpoints are identifiable; localization by measurement agrees with mitotic data and shows the translocations to be reciprocal. Synapsis with the Y is inhibited in one translocation in which the breakpoint is the pairing region of the X.This publication has 20 references indexed in Scilit:
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