Die Gerinnungsverhältnisse beim lebensfrischen, nichtasphyktischen Neugeborenen nach normaler Geburt und Schwangerschaft

Abstract

Recalctfication-time of the blood in the umbilical cord was measured in 1113 cases. Hyper-coagulability was found in 62%, normal time in 27%, and hypo-coagulability in 11%. Fibrinogen content was determined by the Schulz method, and 95.7% of a sample of 210 cases was found to possess a fibrinogen content above the critical range of 100-150 mg%. Fibrinolytic activity in the umbilical venous blood is considerably higher than nor-mal. Various klnase tests show that except for Factor V, all other factors of Phase 1, as well as the Quick values, are considerably below the norm. Despite the hyperfibrinolytic activity of the umbilical venous blood, and the subnormal factor and Quick values vitamin K prophylaxis is not normally necessary, because of the presence of over-all coagulability and the tendency of the blood to normalize itself soon after birth. However possibility of hemorrhaging in newborn infants should be kept in mind.