CERTAIN BENZIMIDAZOLES, BENZENES, AND RIBOFURANOSYLPURINES AS INHIBITORS OF INFLUENZA B VIRUS MULTIPLICATION

Abstract

Examination of a series of amino, nitro, oxy, thiol, benzyl, and phenyl derivatives of benzimidazole did not reveal compounds of unusually high influenza B virus inhibitory activity or selectivity of action. The low solubility of many compounds interfered with testing. Of 5 benzene derivatives examined 3 showed low and 2 showed high virus inhibitory activity. These compounds were not significantly selective. Among 3 beta-D-ribofuranosylpurines 2 were slightly and 1 was moderately active in inhibiting Lee virus multiplication. Selectivity of these compounds was very low. The very high virus inhibitory activity and moderate selectivity of beta-D-ribofuranosides of certain halogenated benzimidazoles stand out in contrast.