Autophosphorylation of calmodulin kinase II: functional aspects
- 3 February 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 196 (1), 135-138
- https://doi.org/10.1016/0014-5793(86)80228-9
Abstract
Autophosphorylation of purified calmodulin kinase II dramatically inhibited protein kinase activity and enhanced substrate selectivity. Inhibition was observed over a wide range of calmodulin concentrations but calmodulin binding was unaffected. Autophosphorylation of calmodulin kinase II may be a mechanism for limiting phosphorylation to physiological substrates and terminating some of calcium's actions in synaptic eventsKeywords
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