Changing Patterns of Failure in Advanced Head and Neck Cancer
- 1 September 1984
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 110 (9), 564-565
- https://doi.org/10.1001/archotol.1984.00800350006003
Abstract
• We treated 98 previously untreated patients with stages III and IV resectable epidermoid carcinoma of the oral cavity, oropharynx, and larynx with surgery and postoperative radiation therapy. The reasons for postoperative radiation therapy were unsatisfactory surgical margins in 36 patients, cervical metastases at multiple levels pathologically in 49, and both in 13. Historically, patients with similar findings, treated by surgery alone at our institution, had a relapse rate above the clavicles of more than 70% within two years. In the present series only 15% have had relapses above the clavicles, and distant metastases developed in another 20%. In addition, approximately 6% of patients per year have had second malignant neoplasms develop, predominantly in the esophagus or the lung. These changes in the patterns of failure have implications for future studies aimed at improving the cure rate and the survival of these patients. (Arch Otolaryngol 1984;110:564-565)This publication has 6 references indexed in Scilit:
- Failure at distant sites following multimodality treatment for advanced head and neck cancerHead & Neck Surgery, 1984
- Epidermoid carcinoma of the mouth and pharynx at memorial sloan-kettering cancer center, 1965 to 1969The American Journal of Surgery, 1980
- The significance of “positive” margins in surgically resected epidermoid carcinomasHead & Neck Surgery, 1978
- An analysis of distant metastases from squamous cell carcinoma of the upper respiratory and digestive tractsCancer, 1977
- Epidermoid carcinoma of the mouth and pharynx 1960–1964The Journal of Laryngology & Otology, 1972
- Preoperative Radiation and Radical Neck DissectionSurgical Clinics of North America, 1969