Nonrandom Cytogenetic Abnormalities in Dupuytren's Disease

Abstract

To the Editor: We cultured fibroblasts from the nodule in the diseased palmar fascia and from the unaffected palmar skin of the same hand of 26 unrelated, randomly selected patients undergoing surgery for Dupuytren's disease. Five patients had bilateral operations. Clinically, this disease is defined as a benign pathologic change in the palmar and digital fascia that results in flexion contraction of the fingers.¹ The fibroblasts were cultured for four weeks, and the chromosomes examined by the quinacrine fluorescent banding method.² If three or more metaphase spreads from replicate flasks contained the same chromosome abnormality, these cells were considered to . . .