In vivo localized ESR spectroscopy reflecting metabolism
- 1 May 1989
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 10 (2), 266-272
- https://doi.org/10.1002/mrm.1910100211
Abstract
Localized electron spin resonance spectroscopy in Live mice was performed using a surface coil operating at 1.1 GHz with sufficient sensitivity and stability to measure quantitatively the time course of the distribution, uptake, and reduction of nitroxides in selected organsfregions (liver, bladder, head) of mice. The ability to measure regional concentrations of nitroxides in vivo could be used for pharmacokinetic analysis of drugs labeled with nitroxides and for measurement of oxygen concentrations and redox metabolism. © 1989 Academic Press, Inc.This publication has 17 references indexed in Scilit:
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