Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol
- 1 July 1968
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 108 (4), 577-582
- https://doi.org/10.1042/bj1080577
Abstract
1. The ring-fission of cis- and trans-acenaphthene-1,2-diol by rat liver microsomes was studied. 2. 1,8-Naphthalic acid was detected and isolated after microsomal incubations of the diols. 3. The accompanying reduction of NAD+ was followed spectrophotometrically. 4. The optimum pH for the microsomal reaction was 9·4 for the oxidation of the cis-diol and 9·8 for that of the trans-diol. 5. p-Chloromercuribenzoate and 2,4-dichlorophenol inhibited the reaction. 6. Possible mechanisms for the microsomal ring-fission, involving 1,8-naphthalic aldehyde, are discussed.Keywords
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