Citrovorum Factor and Oviduct Response to Stilbestrol in Aminopterin-Treated Chicks
- 1 January 1951
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 76 (1), 203-205
- https://doi.org/10.3181/00379727-76-18436
Abstract
Citrovorum Factor (CF) in a ratio to aminopterin of approx. 16:1, but not of 2:1, counteracts aminopterin inhibition of stilbestrol stimulation of the chick oviduct, while pteroylglutamic acid (PGA) in a ratio to aminopterin of 500:1 is 81% effective in this regard. That CF can substitute for PGA in permitting stilbestrol stimulation of the chick oviduct is further evidence consistent with the theory that CF is a metabolically active form of PGA.Keywords
This publication has 6 references indexed in Scilit:
- On the Mechanism of Action of Aminopterin.Experimental Biology and Medicine, 1950
- Synthesis of Citrovorum Factor From Folic Acid By Liver Slices; Augmentation By Ascorbic Acid.Experimental Biology and Medicine, 1950
- Reversal of Aminopterin Inhibition in the Chick Embyro with Desoxyribosides.Experimental Biology and Medicine, 1950
- THE EFFECT OF FOLIC ACID ON THE TOXICITY OF ITS ANALOGUE 4-AMINOPTEROYLGLUTAMIC ACID (AMINOPTERIN)Blood, 1949
- Effect of Folic Acid, "4-Amino" Folic Acids and Related Substances on Growth of Chick Embryo.Experimental Biology and Medicine, 1949
- 4-Amino Pteroylglutamic Acid (Aminopterin), Pteroylglutamic (Folic) Acid, and Response of Frogs, Rana clamitans, to Estrogens.Experimental Biology and Medicine, 1948