EFFECTS OF CORTISONE ON THYROID FUNCTION IN WHITE LEGHORN COCKERELS1,2

Abstract

ALTHOUGH cortisone has been shown to depress thyroid collection of radioactive iodine in rats by Money et al. (1950), Money et al. (1951), Perry (1951), Paschkis et al. (1952), Albert et al. (1952), Rawson (1952), Vezar and Vidovic (1952), Ingbar (1953), Ingbar and Chandler (1953) and Epstein et al. (1953), in rabbits by Myant (1953) and in man by Hill et al. (1950), Wolfson et al. (1950), Frederickson (1951), Frederickson et al. (1952), Kuhl and Ziff (1952), Berson and Yalow (1952) and Zingg and Perry (1953), the data on the mechanism whereby this reduced uptake is accomplished are not conclusive. The present report describes experiments designed to determine whether a similar effect occurs in the chick thyroid and to provide data which might suggest the possible mechanism involved. White Leghorn males were given 3 hormone injections spaced 12 hours apart beginning the evening they were hatched.