Cholesterol Hydroperoxide Formation in Red Cell Membranes and Photohemolysis in Erythropoietic Protoporphyria
- 16 March 1973
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 179 (4078), 1131-1133
- https://doi.org/10.1126/science.179.4078.1131
Abstract
3β-Hydroxy-5α-hydroperoxy-Δ6-cholestene is produced in protoporphyrin-containing red blood cell ghosts irradiated with approximately 400-nanometer light in the presence of oxygen. Incorporation of this cholesterol photooxidation product into normal red blood cells leads to increased osmotic fragility and eventual hemolysis. These results may be relevant to photohemolysis associated with erythropoietic protoporphyria.Keywords
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