HORMONAL-STIMULATION OF ADENOSINE 3', 5'-CYCLIC MONOPHOSPHATE FORMATION IN CELL-FREE PARTICLES AND INTACT-CELLS OF SMOOTH-MUSCLE IN AORTA AND FEMORAL-ARTERY OF RATS DURING IMMOBILIZATION STRESS

Abstract

The ability of adrenaline and histamine to stimulate the formation of cyclic[c]AMP was investigated in broken cell preparation and intact cells of smooth muscle of the aorta and femoral artery of rats which had been subjected to daily intermittent immobilization for 1, 3 and 17 wk. This type of stress led to an instability of the blood pressure which was associated with an increased sensitivity of adenylate cyclase in the broken cell preparations from the arteries to adrenaline and histamine and with a heightened cAMP response to the 2 hormones in the intact arterial smooth muscle cells. The sensitivity of cardiac adenylate cyclase for adrenaline remained unchanged.