Effects of simultaneous oral–intragastric ingestion on meal patterns and satiety in humans.

Abstract

Simultaneous oral-intragastric ingestion of a liquid diet was compared with oral ingestion for 15-21 days in 4 males of normal wt, 18-21 yr old. All the subjects ate significantly more during simultaneous ingestion compared with oral lunches and dinners. Subjects reduced the size and frequency of breakfasts and snacks, which were always ingested orally, and did not gain weight. In a 2nd experiment, the same 4 subjects ate significantly more at lunch when the rate of ingestion was 200 cm3/min compared with 100 cm3/min regardless of route (oral, intragastric or simultaneous). They also ate significantly more during simultaneous meals compared with oral or intragastric meals ingested at the same rate. Rate of ingestion and oral stimulation are important determinants of meal size in humans.