Deletion Mapping of Chromosome 10 in Human Glioma
- 1 April 1996
- journal article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 87 (4), 363-367
- https://doi.org/10.1111/j.1349-7006.1996.tb00231.x
Abstract
We analyzed DNAs from 35 gliomas (27 malignant, grades III and IV; 8 less malignant, grades I and II) for loss of heterozygosity (LOH) using microsatellite sequences on chromosome 10 as polymorphic markers. An LOH was found in 8 of 11 (73%) glioblastomas (grade IV) and 4 of 16 (25%) grade III gliomas, but not in the less malignant types. We detected three commonly deleted regions. One was located in a telomeric region of 10p and the others were relatively large regions of 10q. Our results suggested that three putative tumor suppressor genes on chromosome 10 are involved in the malignant progression of gliomas.Keywords
This publication has 30 references indexed in Scilit:
- Two tumor suppressive loci on chromosome 10 involved in human glioblastomasGenes, Chromosomes and Cancer, 1995
- The 1993–94 Généthon human genetic linkage mapNature Genetics, 1994
- A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor TypesScience, 1994
- Deletion mapping of the long arm of chromosome 10 in glioblastoma multiformeGenes, Chromosomes and Cancer, 1993
- Chromosome 11p15 deletions in human malignant astrocytomas and primitive neuroectodermal tumorsGenomics, 1992
- Correlation of cytogenetic analysis and loss of heterozygosity studies in human diffuse astrocytomas and mixed oligo‐astrocytomasGenes, Chromosomes and Cancer, 1992
- Loss of heterozygosity for 10q loci in human gliomasGenes, Chromosomes and Cancer, 1992
- Allelotyping of human prostatic adenocarcinomaGenomics, 1991
- Deletion mapping of chromosomes 8, 10, and 16 in human prostatic carcinomaGenes, Chromosomes and Cancer, 1991
- Loss of heterozygosity on chromosome 10 in human glioblastoma multiformeGenomics, 1989