Comparative antimicrobial activity of the new macrolide flurithromycin against respiratory pathogens

Abstract

The activity of flurithromycin againstHaemophilus influenzae, Streptococcus pneumoniae, Streptococcus pyogenes, Branhamella catarrhalis andStaphylococcus aureus was determined by the agar dilution method. Flurithromycin showed high activity againstStreptococcus pneumoniae, Streptococcus pyogenes andBranhamella catarrhalis (MIC90=0.032–0.25 mg/l). Its MIC90 value againstHaemophilus influenzae strains was 4.0 mg/l and 16 mg/l againstStaphylococcus aureus strains. Flurithromycin has promising antibacterial activity which warrants clinical trials.