A COMPARISON OF AMPHETAMINE SULFATE WITH OTHER STIMULANTS OF THE CENTRAL NERVOUS SYSTEM IN MORPHINE RESPIRATORY DEPRESSION

Abstract

The effectiveness of amphetamine was compared with several stimulants of the C.N.S. commonly used in acute morphine poisoning. Fourteen human subjects were used after they had been tested for idiosyncrasy to morphine. Avg. % increases in minute volume above the depressed levels were as follows: amphetamine 102%, nikethamide 37%, ephedrine 30%, metrazol 21%, and caffeine 17%.