Influence of ACTH upon Avian Species and Osteoporosis.

Abstract

White Leghorn hens bred for heavy egg production developed severe osteoporosis following injections of adrenocorticotropic hormone (ACTH) varying from 7 to 770 mg during periods from 14 to 49 days. Similar treatment did not produce osteoporosis in roosters. The level of corticosterone in the plasma was increased from 8 to 15 [mu]g/100 cc. Ovarian weight and egg production were decreased only at the end of the period of treatment. Osteoporosis was measured by the reduction in thickness of the cortical bone of the femur and tibia. This form of osteoporosis is found in the disorder of modern poultry known as "cage layer fatigue", and may be related to ACTH metabolism.