Leucocyte migration inhibition as a model for the demonstration of sensitized cells in East Coast fever.

  • 1 December 1974
    • journal article
    • Vol. 27 (6), 1033-7
Abstract
Bovine peripheral leucocytes were used in a migration inhibition test to detect sensitization to Theileria parva antigens. Seventy-six per cent of animals that were exposed to T. parva antigens yielded sensitive cells. The reaction was most efficiently induced by use of living T. parva. Migration of cells from control animals was not inhibited. In some animals the presence of sensitive cells in the peripheral circulation was shown to persist for up to 8 months after exposure to experimental T. parva infection. The significance of cells that are sensitive to T. parva antigens in East Coast fever is not known.