Falciparum malaria cured by quinine followed by sulfadoxine-pyrimethamine.
- 5 April 1975
- Vol. 2 (5961), 15-17
- https://doi.org/10.1136/bmj.2.5961.15
Abstract
Quinine (at least four doses given at intervals of eight to 12 hours) followed by a single dose of sulfadoxine-pyrimethamine (Fansidar) is the most effective treatment of chloroquine-resistant falciparum malaria. This regimen cured 96% of patients (302 out of 314) with an average initial parasite count of 90 X 10-9/1.Keywords
This publication has 10 references indexed in Scilit:
- Quinine fever in falciparum malaria.1974
- Malaria in Birmingham 1968-73BMJ, 1974
- Human plasma and urine quinine levels following tablets, capsules, and intravenous infusionClinical Pharmacology & Therapeutics, 1973
- The Combined Action of Pyrimidines and Sulfonamides or Sulfones in the Chemotherapy of Malaria and Other Protozoal InfectionsPublished by Elsevier ,1971
- Malaria: Host-Defense Mechanisms and ComplicationsAnnals of Internal Medicine, 1970
- Pharmacokinetics of Sulfamethoxazole + Trimethoprim in Man and Their Distribution in the RatChemotherapy, 1970
- Quinine, pyrimethamine, and sulphorthodimethoxine: Clinical response, plasma levels, and urinary excretion during the initial attack of naturally acquired falciparum malariaClinical Pharmacology & Therapeutics, 1969
- The Evaluation of Sulfonamides, Alone or in Combination with Pyrimethamine, in the Treatment of Multi-Resistant Falciparum MalariaThe American Journal of Tropical Medicine and Hygiene, 1966
- Antimalarial Effect of Sulphorthodimethoxine (Fanasil)BMJ, 1964
- Persistent Excretion of Pyrimethamine Following Oral AdministrationThe American Journal of Tropical Medicine and Hygiene, 1959