KAPOSI'S SARCOMA: IMMUNOPEROXIDASE STAINING FOR CYTOMEGALOVIRUS
- 1 January 1983
- journal article
- Published by Mary Ann Liebert Inc in AIDS Research
- Vol. 1 (2), 121-125
- https://doi.org/10.1089/aid.1.1983.1.121
Abstract
An immunoperoxidase technique was used to test for cytomegalovirus (CMV) proteins in lesions of Kaposi's sarcoma from 19 patients with acquired immune deficiency syndrome (AIDS) and 3 patients without AIDS. CMV proteins could not be detected in any of the cases of Kaposi's sarcoma. Thus, while CMV genetic material may be present in these cells, the virus is not actively directing the synthesis of proteins. This eliminates reactivation of latent CMV in tumor tissue, or late infection of Kaposi's sarcoma cells as explanations for the elevated antibody titers to CMV and other evidence of CMV infection in patients with Kaposi's sarcoma. However, the possibility remains that exposure to CMV occurs as a primary event in the development of Kaposi's sarcoma. These findings indicate that, as in Kaposi's sarcoma of the elderly, the virus is inactive in Kaposi's sarcoma cells of patients with AIDS, and there is no difference between the two lesions in immunoperoxidase staining for CMV proteins.Keywords
This publication has 7 references indexed in Scilit:
- Kaposi's sarcoma following chemotherapy for testicular cancer in a homosexual man: Demonstration of cytomegalovirus RNA in sarcoma cellsHuman Pathology, 1982
- Kaposi's Sarcoma: Absence of Cytomegalovirus AntigensJournal of Investigative Dermatology, 1982
- CYTOMEGALOVIRUS AND KAPOSI'S SARCOMA IN YOUNG HOMOSEXUAL MENThe Lancet, 1982
- Prevalence of Cytomegalovirus Infection in Homosexual MenThe Journal of Infectious Diseases, 1981
- Antibody patterns to herpesviruses in Kaposi's sarcoma. II. Serological association of american Kaposi's sarcoma with cytomegalovirusInternational Journal of Cancer, 1978
- Antibody patterns to herpesviruses in kaposi's sarcoma: Serological association of european kaposi's sarcoma with cytomegalovirusInternational Journal of Cancer, 1975
- THE UNLABELED ANTIBODY ENZYME METHOD OF IMMUNOHISTOCHEMISTRY PREPARATION AND PROPERTIES OF SOLUBLE ANTIGEN-ANTIBODY COMPLEX (HORSERADISH PEROXIDASE-ANTIHORSERADISH PEROXIDASE) AND ITS USE IN IDENTIFICATION OF SPIROCHETESJournal of Histochemistry & Cytochemistry, 1970